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Corosolic acid

Names

[ CAS No. ]:
52213-27-1

[ Name ]:
Corosolic acid

[Synonym ]:
(2α,3α)-2,3-Dihydroxyurs-12-en-28-oic acid
Corosolic acid
Urs-12-en-28-oic acid, 2,3-dihydroxy-, (2α,3β)-
Urs-12-en-28-oic acid, 2,3-dihydroxy-, (2α,3α)-
2,3-Dihydroxy-urs-12-en-28-oic acid
2α-Hydroxyursolic acid
(2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid

Biological Activity

[Description]:

Pygenic acid A is a natural compound that can be found in Prunella vulgaris. Pygenic acid A induces apoptosis in metastatic breast cancer cells. Pygenic acid A can be used for the research of diabetes, inflammatory diseases, and cancers[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[In Vitro]

Pygenic acid A sensitizes metastatic breast cancer cells to anoikis via multiple pathways, such as inhibition of pro-survival pathways and activation of ER stress and autophagy, leading to the inhibition of metastasis[1].

[References]

[1]. Ga-Eun Lim, et al. Pygenic Acid A (PA) Sensitizes Metastatic Breast Cancer Cells to Anoikis and Inhibits Metastasis In Vivo. Int J Mol Sci. 2020 Nov; 21(22): 8444.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
573.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H48O4

[ Molecular Weight ]:
472.700

[ Flash Point ]:
314.6±26.6 °C

[ Exact Mass ]:
472.355255

[ PSA ]:
77.76000

[ LogP ]:
7.82

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.567

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds