DL-α-Tocopherol acetate

Names

[ Name ]:
DL-α-Tocopherol acetate

[Synonym ]:
6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol Acetate
MFCD00072042
EINECS 231-710-0
DL-α-TOCOPHEROL ACETATE
DL-alpha-tocopherol acetate

Biological Activity

[Description]:

DL-α-Tocopherol acetate is a vitamin E derivative which is often included in the formulations of enteral nutrition.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vivo]

DL-α-Tocopherol acetate is a vitamin E derivative which is often included in the formulations of enteral nutrition[1]. DL-α-Tocopherol acetate (α-TA) increases tissue cholesterol levels in liver, brian, testis and herart. The brain cholesterol level is much higher than those in other tissues when adjusted by protein level. DL-α-Tocopherol acetate also increases the level of lipid peroxidation in liver, brain, and testis of mice[2].

[Animal admin]

Male mice (specific-pathogen-free, 4 weeks of age) are divided into three groups. They are fed for 4 weeks with the CE2 diet containing one of three different antioxidants, 0.002 wt% DL-α-Tocopherol acetate (α-TA) (n=6), 0.02 wt% α-T (n=6) or 0.02 wt% α-TP(CD3) (n=7), per kilogram of diet. The mice are maintained under standardized conditions of light (7:00 AM to 7:00 PM), temperature (22°C), and humidity (70%). After 4 weeks, they are sacrificed under anesthesia with diethyl ether. The extracted brain, liver, heart, kidney, testis, and lung are homogenized in ice-cold 10 mM phosphate-buffered saline. Blood samples are collected in heparincontaining tubes. The samples are placed on ice immediately after collection. Plasma is obtained by centrifugation at 830 g for 5 min at 4°C and immediately subjected to analysis[2].

[References]

[1]. Nagy K, et al. Double-balloon jejunal perfusion to compare absorption of vitamin E and vitamin E acetate in healthy volunteers under maldigestion conditions. Eur J Clin Nutr. 2013 Feb;67(2):202-6.

[2]. Nishio K, et al. α-Tocopheryl phosphate: uptake, hydrolysis, and antioxidant action in cultured cells and mouse. Free Radic Biol Med. 2011 Jun 15;50(12):1794-800.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
485.3±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₁H₅₂O₃

[ Molecular Weight ]:
472.743

[ Flash Point ]:
235.6±24.7 °C

[ Exact Mass ]:
472.391632

[ PSA ]:
35.53000

[ LogP ]:
12.07

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.488

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2890100

CHEMICAL NAME :: 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltr idecyl)-, acetate, (2R*(4R*,8R*))-(+-)-

CAS REGISTRY NUMBER :: 52225-20-4

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C31-H52-O3

MOLECULAR WEIGHT :: 472.83

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8320 mg/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 82,511,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4647 No. of Facilities: 130 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 9320 (estimated) No. of Female Employees: 3204 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319

[ Precautionary Statements ]:
P210-P305 + P351 + P338

[ RIDADR ]:
UN 1648 3 / PGII

[ WGK Germany ]:
1

[ RTECS ]:
GA8747000