5,7-Dihydroxy-6-(3-methyl-2-butenyl)-8-(3-methylbutyryl)-4-phenyl-2H-1-benzopyran-2-one

Names

[ Name ]:
5,7-Dihydroxy-6-(3-methyl-2-butenyl)-8-(3-methylbutyryl)-4-phenyl-2H-1-benzopyran-2-one

[Synonym ]:
Mammea A/BA
isomammeisin

Biological Activity

[Description]:

Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, ROS production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Infection

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

Signaling Pathways >> Autophagy >> Autophagy

[Target]

T. cruzi[1]

[References]

[1]. Rodríguez-Hernández KD, et al. Mammea type coumarins isolated from Calophyllum brasiliense induced apoptotic cell death of Trypanosoma cruzi through mitochondrial dysfunction, ROS production and cell cycle alterations. Bioorg Chem. 2020 Jul;100:103894.

Chemical & Physical Properties

[ Density]:
1.219g/cm3

[ Boiling Point ]:
629.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₅H₂₆O₅

[ Molecular Weight ]:
406.47100

[ Flash Point ]:
215.3ºC

[ Exact Mass ]:
406.17800

[ PSA ]:
87.74000

[ LogP ]:
5.60870

[ Index of Refraction ]:
1.607

5,7-Dihydroxy-6-(3-methyl-2-butenyl)-8-(3-methylbutyryl)-4-phenyl-2H-1-benzopyran-2-one

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds