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m-PEG5-SH

Names

[ CAS No. ]:
524030-00-0

[ Name ]:
m-PEG5-SH

[Synonym ]:
3,6,9,12,15-pentaoxahexadecane-1-thiol

Biological Activity

[Description]:

m-PEG5-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.048

[ Molecular Formula ]:
C11H24O5S

[ Molecular Weight ]:
268.37000

[ Exact Mass ]:
268.13400

[ PSA ]:
84.95000

[ LogP ]:
0.62900

[ Storage condition ]:
2-8°C


Related Compounds