Chlorthalidone impurity

Names

[ Name ]:
Chlorthalidone impurity

[Synonym ]:
Chlorthalidone Related Compound A
2-[3-(Aminosulfonyl)-4-chlorobenzoyl]-benzonic Acid
2-(4-Chloro-3-sulphamoylbenzoyl)benzoic acid
EINECS 226-089-8

Biological Activity

[Description]:

Chlorthalidone impurity is a metabolite of Chlorthalidone (HY-15833). Chlorthalidone is a thiazide-like diuretic used to treat hypertension[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Bauer J, et al. Stability-indicating assay for chlorthalidone formulation: evaluation of the USP analysis and a high-performance liquid chromatographic analysis. J Pharm Sci. 1983 Aug;72(8):924-8.

[2]. Barrios V, et al. Which thiazide to choose as add-on therapy for hypertension? Integr Blood Press Control. 2014 Jul 30;7:35-47.

Chemical & Physical Properties

[ Density]:
1.537g/cm3

[ Boiling Point ]:
638.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₁₀ClNO₅S

[ Molecular Weight ]:
339.75

[ Flash Point ]:
340ºC

[ Exact Mass ]:
338.99700

[ PSA ]:
122.91000

[ LogP ]:
3.69770

[ Index of Refraction ]:
1.641

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%