D-Leucinol

Names

[ Name ]:
D-Leucinol

[Synonym ]:
(R)-LEUCINOL
H-D-LEU-OL
(R)-2-Amino-4-methylpentan-1-ol
H-D-LEUCINOL
D-eucinol
(R)-(-)-2-amino-4-methylpentan-1-ol
D(-)-Leucinol ee
1-Pentanol, 2-amino-4-methyl-, (2R)-
D-(-)-Leucinol
D(-)-Leucinol
(2R)-2-Amino-4-methyl-1-pentanol
MFCD00004734
(R)-(-)-Leucinol
(R)-(-)-2-Amino-4-methyl-1-pentanol
(1R)-1-(hydroxymethyl)-3-methylbutylamine
(R)-(−)-Leucinol
(2R)-2-amino-4-methylpentan-1-ol

Biological Activity

[Description]:

D-Leucinol is the inactive isomer of L-Leucinol (HY-W015876), and can be used as an experimental control. L-Leucinol ((+)-Leucinol) is a competitive aminopeptidase inhibitor with Ki value of 17 μM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Bienvenue DL, et al. Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinethiol: kinetic and spectroscopic characterization of a slow, tight-binding inhibitor-enzyme complex. J Inorg Biochem. 2000 Jan 15;78(1):43-54.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
198.6±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₁₅NO

[ Molecular Weight ]:
117.19

[ Flash Point ]:
78.6±19.8 °C

[ Exact Mass ]:
117.115364

[ PSA ]:
46.25000

[ LogP ]:
0.45

[ Vapour Pressure ]:
0.1±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.450

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R22;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
NA 1993 / PGIII

[ WGK Germany ]:
3

[ HS Code ]:
2922199090

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Nat. Chem. Biol. 5 , 45-52, (2009)

Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting tr...