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1-Hydroxyrutaecarpine

Names

[ CAS No. ]:
53600-24-1

[ Name ]:
1-Hydroxyrutaecarpine

[Synonym ]:
6-Methylmercapto-hexan-1-ol
7-thiaoctanol
1-hydroxyrutaecarpine
Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-1-hydroxy-
6-methylsulfanyl-hexan-1-ol
1-Hydroxy-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
1-Hydroxy-7-thiaoctane

Biological Activity

[Description]:

1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED50s of 3.72, 7.44 µg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity[1][2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Bruno Danieli; et al. 1-Hydroxyrutaecarpine from Euxylophora paraënsis. Phytochemistry, 1974 , 13(8), 1603–1606.

[2]. Chen JJ, et al. New indolopyridoquinazoline, benzo[c]phenanthridines and cytotoxic constituents from Zanthoxylum integrifoliolum. Planta Med. 2005 May;71(5):470-5.

[3]. Sheen WS, et al. Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum. Planta Med. 1996 Apr;62(2):175-6.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
601.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H13N3O2

[ Molecular Weight ]:
303.31

[ Flash Point ]:
317.7±34.3 °C

[ Exact Mass ]:
303.100769

[ PSA ]:
70.91000

[ LogP ]:
1.29

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.818

Related Compounds