Corylin

Names

[ Name ]:
Corylin

[Synonym ]:
2,2,8-trimethyl-7-hydroxychromanone
Corylin
7-hydroxy-2,2,8-trimethyl-2,3-dihydro-4H-benzopyran-4-one
isowighteone
2,3-dihydro-7-hydroxy-2,2,8-trimethyl-4H-benzopyran-4-one
7-Hydroxy-2,2,8-trimethylchroman-4-one
7-Hydroxy-2,2,8-trimethyl-4-chromanone
7-HYDROXY-2,2,8-TRIMETHYL-2,3-DIHYDRO-4H-CHROMEN-4-ONE
4H-1-Benzopyran-4-one, 3-(2,2-dimethyl-2H-1-benzopyran-6-yl)-7-hydroxy-
7-Hydroxy-2',2'-dimethyl-2'H,4H-3,6'-bichromen-4-one

Biological Activity

[Description]:

Corylin is a major bioactive compound isolated from Psoralea corylifolia L; antibiotic or anticancer compound.IC50 value:Target: in vitro: Corylin showed an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 value of 1.37 uM [1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Natural Products >> Flavonoids

Research Areas >> Cancer

[References]

[1]. Lee SW, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012 Jun;78(9):903-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
527.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₆O₄

[ Molecular Weight ]:
320.339

[ Flash Point ]:
193.1±23.6 °C

[ Exact Mass ]:
320.104858

[ PSA ]:
59.67000

[ LogP ]:
4.45

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.637

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914400090

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%