Pirozadil

Names

[ Name ]:
Pirozadil

[Synonym ]:
2,6-Pyridinediyldimethylene bis(3,4,5-trimethoxybenzoate)
2,6-Pyridinediylbis(methylene) 3,4,5-trimethoxybenzoate
Benzoic acid,3,4,5-trimethoxy-,2,6-pyridinediylbis(methylene) ester
EINECS 258-978-1
Pirozadil
722 d
Pirozadilum [INN-Latin]
Pemix
2,6-Pyridinedimethanol bis(3,4,5-trimethoxybenzoate)

Biological Activity

[Description]:

Pirozadil is a hypolipidemic agent.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vivo]

Pirozadil is a hypolipidemic agent. Pirozadil's effect on increasing cerebral blood flow is almost equal to that of papaverine, less than that of nicardipine and much greater than that of the other hypolipidemic/antiatherogenic drugs, nicotinic acid and pyridinol carbamate. Pirozadil is also shown to significantly diminish vascular cerebral resistance to a much greater degree than nicotinic acid and pyridinol carbamate[1].

[References]

[1]. Roca J, et al. Effect of pirozadil on cerebral blood flow in anesthetized dogs. Methods Find Exp Clin Pharmacol. 1981 Nov-Dec;3(6):397-401.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.244g/cm3

[ Boiling Point ]:
594ºC at 760mmHg

[ Molecular Formula ]:
C₂₇H₂₉NO₁₀

[ Molecular Weight ]:
527.52000

[ Flash Point ]:
313ºC

[ Exact Mass ]:
527.17900

[ PSA ]:
120.87000

[ LogP ]:
3.84720

[ Index of Refraction ]:
1.559

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI0878200

CHEMICAL NAME :: Benzoic acid, 3,4,5-trimethoxy-, 2,6-pyridinediylbis(methylene) ester

CAS REGISTRY NUMBER :: 54110-25-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C27-H29-N-O10

MOLECULAR WEIGHT :: 527.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AFTOD7 Archivos de Farmacologia y Toxicologia. (Universidad Complutense, Facultad de Medicina, Departamento Coordinado de Farmacologia, Ciudad Universitaria, Madrid 3, Spain) V.1- 1975- Volume(issue)/page/year: 6,41,1980

Safety Information

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%