4β-Hydroxywithanolide E

Names

[ Name ]:
4β-Hydroxywithanolide E

Biological Activity

[Description]:

4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

Research Areas >> Metabolic Disease

[References]

[1]. Momochika Kumagai, et al. 4β-Hydroxywithanolide E and withanolide E from Physalis peruviana L. inhibit adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. J Nat Med. 2021 Jan;75(1):232-239.

Chemical & Physical Properties

[ Density]:
1.39g/cm3

[ Boiling Point ]:
728.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₃₈O₈

[ Molecular Weight ]:
502.59700

[ Flash Point ]:
242.1ºC

[ Exact Mass ]:
502.25700

[ PSA ]:
136.82000

[ LogP ]:
1.72520

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KE7283000

CHEMICAL NAME :: Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, delta-lactone, (4-beta,5-beta,6-beta,17-alpha,22R)-

CAS REGISTRY NUMBER :: 54334-04-2

LAST UPDATED :: 198605

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C28-H38-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 31050 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986