GATA4-IN-3

Names

[ Name ]:
GATA4-IN-3

Biological Activity

[Description]:

GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[Target]

IC50: 3 μM (GATA4–NKX2-5)[1]

[References]

[1]. Välimäki MJ, et al. Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5. J Med Chem. 2017 Sep 28;60(18):7781-7798.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₃N₃O₂

[ Molecular Weight ]:
349.43

GATA4-IN-3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds