Verbascose

Names

[ CAS No. ]:
546-62-3

[ Name ]:
Verbascose

[Synonym ]:
MELITOSE
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MELITOSE PENTAHYDRATE
2-(BENZYLAMINO)-3-[(Z)-(4-OXO-3-PROPYL-2-THIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
RAFFINOSE PENTAHYDRATE
RAFFINOSE,5-HYDRATE
GOSSYPOSE PENTAHYDRATE

Biological Activity

[Description]:

Verbascose, an alacto-oligosac-charides (GOS), has potent immunostimulatory activity. Verbascose acts as a potential natural immunomodulatory agent[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Verbascose (25, 50, 100, 200, 400 μg/mL; 12, 24, 36, 48 hours) significantly increases the viability of RAW264.7 cells[1]. Verbascose has notable activity of promoting peritoneal macrophages to devour neutral red in a dose-dependent manner and exhibits its maximum activity of cell phagocytosis at a concentration of 200 μg/mL[1]. Verbascose induces significant increases of NO production. Verbascose can enhance the ability of devouring neutral red of peritoneal macrophages and promote the release of nitric oxide and immune reactive molecules such as interleukin (IL)-6, IL-1β, interferon (IFN)-α, and IFN-γ[1].

[In Vivo]

Verbascose (30, 90, 120 mg/kg/day; sc; for 8 days) at a medium dose of 90 mg/kg body weight can significantly increase the index of spleen, activity of lysozyme in spleen and serum, hemolysin level in serum, and swelling rate of earlap in the delayed type of hypersensitivity (DTH) of immunosuppressed female Kunming mice[1].

[References]

[1]. Zhuqing Dai, et al. Immunomodulatory activity in vitro and in vivo of verbascose from mung beans (Phaseolus aureus). J Agric Food Chem. 2014 Nov 5;62(44):10727-35.

Chemical & Physical Properties

[ Density]:
1.86g/cm3

[ Boiling Point ]:
1185ºC at 760mmHg

[ Melting Point ]:
219-220°; mp 253°

[ Molecular Formula ]:
C₃₀H₅₂O₂₆

[ Molecular Weight ]:
828.71800

[ Flash Point ]:
670.5ºC

[ Exact Mass ]:
828.27500

[ PSA ]:
426.98000

[ Index of Refraction ]:
1.699

[ Storage condition ]:
2-8°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Nutritional potential of rice bean (Vigna umbellata): an underutilized legume.

J. Food Sci. 78(1) , C8-16, (2013)

Rice bean, a less known and underutilized legume, has emerged as a potential legume because of its nutritional potential. The nutritional quality of rice bean is higher as compared to many other legum...

Levansucrase and sucrose phoshorylase contribute to raffinose, stachyose, and verbascose metabolism by lactobacilli

Food Microbiol. 31(2) , 278-84, (2012)

Raffinose family oligosaccharides (RFOs) in food are considered anti-nutritional factors. This study elucidated the role of α-galactosidase (α-Gal), levansucrase, and sucrose phosphorylase for convers...

Quantitation of α-galactosides in Rehmannia glutinosa by hydrophilic interaction chromatography-evaporative light scattering detector.

Phytochem. Anal. 23(6) , 607-12, (2012)

The use of raffinose family oligosaccharides (RFOs) to control several diseases and stimulate immune systems has been studied. Rehmannia glutinosa is reported to contain RFOs; however, there are no re...