(4aα)-2-Methylene-5,5,8aβ-trimethyldecalin-1β-methanol

Names

[ Name ]:
(4aα)-2-Methylene-5,5,8aβ-trimethyldecalin-1β-methanol

[Synonym ]:
Albicanol

Biological Activity

[Description]:

Albicanol is a sesquiterpenoid with potent antioxidant and antagonistic activities against heavy metal toxicity. Albicanol shows cytotoxicity. Albicanol suppress profenofos (HY-B0832) induced genotoxicity in grass carp hepatocytes[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Albicanol (compound 6) (0-30 µM; 48 h) 显示细胞毒性，对 A549、MCF7、HepG2 细胞的 IC50 值分别 >30、24.14、>30 µM[1 ]. Albicanol (0.00005 µg/mL; 24 h) 显着抑制 L8824 细胞因 PFF 暴露而产生的遗传毒性[2]。 Cell Cytotoxicity Assay[1] Cell Line: A549, MCF7, HepG2 cells Concentration: 0-30 µM Incubation Time: 48 h Result: Showed cytotoxicity with IC50s of >30, 24.14, >30 µM for A549, MCF7, HepG2 cells, respectively.

[References]

[1]. Zhao DD, et al. Compounds from Dryopteris fragrans (L.) Schott with cytotoxic activity. Molecules. 2014 Mar 18;19(3):3345-55.

[2]. Lihui X, et al. Albicanol modulates oxidative stress and the p53 axis to suppress profenofos induced genotoxicity in grass carp hepatocytes. Fish Shellfish Immunol. 2022 Mar;122:325-333.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₆O

[ Molecular Weight ]:
222.36600

[ Exact Mass ]:
222.19800

[ PSA ]:
20.23000

[ LogP ]:
3.77750

Safety Information

[ HS Code ]:
2906199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2906199090

[ Summary ]:
2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%