(Z)-p-cyano-α-Cyanostilbene

Names

[ CAS No. ]:
54676-54-9

[ Name ]:
(Z)-p-cyano-α-Cyanostilbene

[Synonym ]:
4-(1-cyano-2-phenylvinyl)benzonitrile
4-((Z)-1-Cyano-2-phenyl-vinyl)-benzonitrile

Biological Activity

[Description]:

(Z)-p-cyano-α-Cyanostilbene (compound 11), a phenantrene derivative, has antiproliferative activity. (Z)-p-cyano-α-Cyanostilbene shows significant selectivity against HeLa (IC50=0.21 µM) and HepG2 (IC50=0.230 µM) cells without cytotoxic against normal skin fibroblasts (IC50>100 µM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Nataša Perin, et al. Antiproliferative activity and mode of action analysis of novel amino and amido substituted phenantrene and naphtho[2,1-b]thiophene derivatives. Eur J Med Chem. 2020 Jan 1;185:111833.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H10N2

[ Molecular Weight ]:
230.26

[ Exact Mass ]:
230.08400

[ PSA ]:
47.58000

[ LogP ]:
3.62246

Related Compounds