norswertianolin

Names

[ Name ]:
norswertianolin

[Synonym ]:
4,6,8-Trihydroxy-9-oxo-9H-xanthen-1-yl β-D-glucopyranoside
9H-Xanthen-9-one, 8-(β-D-glucopyranosyloxy)-1,3,5-trihydroxy-

Biological Activity

[Description]:

Norswertianolin acts as a CSE activator and is isolated from G. acuta. Norswertianolin may be a potential agent for cardiovascular diseases[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[Target]

CSE[2]

[In Vitro]

Norswertianolin (3.125~50 μM; H9c2 cells) has the protective effects on H2O2-induced H9c2 cells. Norswertianolin significantly increases the transcription levels of HO-1 and GCLC in H9c2 cells[1]. Norswertianolin (0~150 μM; HepG2 cells) high concentration increases the CSE protein level[2].

[In Vivo]

Norswertianolin (4.4 mg/kg/day; s.c.; 1 week) improves CSE/H2S production[2]. Norswertianolin treatment attenuates the renal tubular injury in acute I/R. Norswertianolin also reduces I/R-stimulated ROS by DHE fluorescence intensity. Norswertianolin has anti-hypertension effects, inhibits vascular remodeling and reduces inflammation effects[2]. Animal Model: Male Sprague Dawley rats (10~12 weeks)[2] Dosage: 4.4 mg/kg/day Administration: S.c. Result: Improved CSE/H2S production.

[References]

[1]. Ren K, et al. Effects of Four Compounds from Gentianella acuta (Michx.) Hulten on Hydrogen Peroxide-Induced Injury in H9c2 Cells. Biomed Res Int. 2019;2019:2692970. Published 2019 Jan 20.

[2]. Niu Y, et al. Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension. Front Pharmacol. 2021;12:677212. Published 2021 Jul 14. doi:10.3389/fphar.2021.677212

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
833.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₈O₁₁

[ Molecular Weight ]:
422.340

[ Flash Point ]:
300.4±27.8 °C

[ Exact Mass ]:
422.084900

[ PSA ]:
190.28000

[ LogP ]:
-1.66

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.758