m-PEG5-NH2

Names

[ CAS No. ]:
5498-83-9

[ Name ]:
m-PEG5-NH2

[Synonym ]:
2,5,8,11,14-Pentaoxahexadecan-16-amine

Biological Activity

[Description]:

m-PEG5-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.023g/cm3

[ Boiling Point ]:
324.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₂₅NO₅

[ Molecular Weight ]:
251.32000

[ Flash Point ]:
143.5ºC

[ Exact Mass ]:
251.17300

[ PSA ]:
72.17000

[ LogP ]:
0.35820

[ Index of Refraction ]:
1.444

[ Storage condition ]:
2-8°C

Safety Information

[ HS Code ]:
2921199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921199090

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%