Cloprostenol Sodium

Names

[ Name ]:
Cloprostenol Sodium

[Synonym ]:
5-Heptenoic acid, 7-((1R,2R,3R,5S)-2-((1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, monosodium salt, (5Z)-rel-
EINECS 259-439-3
Sodium (5Z)-7-{(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate
(±)-Sodium (Z)-7-((1R*,2R*,3R*,5S*)-2-((E)-(3R*)-4-(m-Chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoate
MFCD00132875
Cloprostenol Sodium
Sodium (5Z)-7-{(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-5-heptenoate
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, sodium salt, (5Z)- (1:1)
UNII:886SAV9675
(5Z)-rel-7-((1R,2R,3R,5S)-2-((1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoic Acid Monosodium Salt
(±)-Cloprostenol sodium

Biological Activity

[Description]:

Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a PGF2α receptor agonist[2] and is a luteolytic agent[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[In Vivo]

Cloprostenol sodium salt (25 μg) decreases plasma progesterone in pregnant rats[1].

[References]

[1]. Salazar H, et al. Luteolytic effects of a prostaglandin analogue, cloprostenol (ICI 80,996), in rats: ultrastructural and biochemical observations. Biol Reprod. 1976 May;14(4):458-72.

[2]. Pastel E, et al. Aldose reductases influence prostaglandin F2α levels and adipocyte differentiation in male mouse and human species. Endocrinology. 2015 May;156(5):1671-84.

[Related Small Molecules]

Dinoprostone | Prostaglandin E1 | E7046 | ONO-AE3-208 | PF 04418948 | Fevipiprant | grapiprant | TG6-10-1 | Taprenepag | GW 627368 | MRE-269 | Ramatroban | AH 6809 | Laropiprant | AZD1981

Chemical & Physical Properties

[ Boiling Point ]:
628ºC at 760 mmHg

[ Melting Point ]:
68-70ºC

[ Molecular Formula ]:
C₂₂H₂₈ClNaO₆

[ Molecular Weight ]:
446.897

[ Flash Point ]:
333.6ºC

[ Exact Mass ]:
446.147217

[ PSA ]:
110.05000

[ LogP ]:
1.86030

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: >10 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R60;R22;R36/37/38

[ Safety Phrases ]:
S53-S26-S36/37/39-S45

[ WGK Germany ]:
3