2,3,5-Tri-O-benzyl-D-ribonolactone

Names

[ Name ]:
2,3,5-Tri-O-benzyl-D-ribonolactone

[Synonym ]:
(3R,4R,5R)-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolan-2-one

Biological Activity

[Description]:

2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.21±0.1 g/cm3

[ Boiling Point ]:
576.8±50.0 °C

[ Melting Point ]:
54-55 °C

[ Molecular Formula ]:
C₂₆H₂₆O₅

[ Molecular Weight ]:
418.48

[ Exact Mass ]:
418.17800

[ PSA ]:
53.99000

[ LogP ]:
4.29940

Safety Information

[ Hazard Codes ]:
Xi

2,3,5-Tri-O-benzyl-D-ribonolactone

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds