Decylubiquinone

Names

[ Name ]:
Decylubiquinone

[Synonym ]:
2-decyl-5,6-dimethoxy-3-methyl-1,4-benzoquinone
decylubiquinone
2,3-dimethoxy-5-methyl-6-(n-decyl)-1,4-benzoquinone
2,3-Dmdb
2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
decylbenzylquinone
MFCD00083306
6-Decylubiquinone
2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone

Biological Activity

[Description]:

Decylubiquinone is an analog of ubiquinone (coenzyme Q10). Decylubiquinone blocks reactive oxygen species (ROS) production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Neurological Disease

[In Vitro]

Decylubiquinone (dUb; 10 μm for 6 hours) exerts its effects on ROS by either inhibition of ROS production by cytochrome bc1 or that it scavenged ROS produced[1]. Decylubiquinone inhibits both the dichlorofluorescein (DCF) fluorescence increase resulting from H2O2 treatment and the DCF fluorescence increase resulting after glutathione (GSH) depletion using diethylmaleate mitochondrially generated ROS)[1]. Cell Viability Assay[1] Cell Line: HL60 cells transfected with bcl-2 (bcl-2) (HL60 B cells) Concentration: 10 μM Incubation Time: 6 hours Result: Attenuated the ROS increase in HL60 (B) cells.

[References]

[1]. Jeffrey S Armstrong, et al. The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III. J Biol Chem. 2003 Dec 5;278(49):49079-84.

Chemical & Physical Properties

[ Density]:
1.02g/cm3

[ Boiling Point ]:
452.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₃₀O₄

[ Molecular Weight ]:
322.43900

[ Flash Point ]:
196.2ºC

[ Exact Mass ]:
322.21400

[ PSA ]:
52.60000

[ LogP ]:
4.48990

[ Index of Refraction ]:
1.487

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36