HISPIDIN

Names

[ CAS No. ]:
555-55-5

[ Name ]:
HISPIDIN

[Synonym ]:
6-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-4-hydroxypyran-2-one
6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone

Biological Activity

[Description]:

Hispidin, a PKC inhibitor and a phenolic compound from Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Cardiovascular Disease

Research Areas >> Metabolic Disease

Signaling Pathways >> TGF-beta/Smad >> PKC

[References]

[1]. Kim DE, et al. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway. Exp Cell Res. 2014 Oct 1;327(2):264-75.

Chemical & Physical Properties

[ Density]:
1.657g/cm3

[ Boiling Point ]:
554.2ºC at 760 mmHg

[ Melting Point ]:
312-315ºC

[ Molecular Formula ]:
C₁₃H₁₀O₅

[ Molecular Weight ]:
246.21500

[ Flash Point ]:
220.1ºC

[ Exact Mass ]:
246.05300

[ PSA ]:
90.90000

[ LogP ]:
1.92700

[ Index of Refraction ]:
1.854

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Anti-inflammatory activity of mushroom-derived hispidin through blocking of NF-κB activation.

J. Sci. Food Agric. 95 , 2482-6, (2015)

Hispidin, a polyphenol compound mainly derived from the valuable medicinal mushroom Phellinus species, has been found to possess distinct biological effects. However, the anti-inflammatory potential o...

Anticancer activity of hispidin via reactive oxygen species-mediated apoptosis in colon cancer cells.

Anticancer Res. 34(8) , 4087-93, (2014)

Few studies have been performed on the anticancer activity of hispidin, a phenolic compound produced from the medicinal mushroom Phellinus linteus. Herein, we studied hispidin-induced apoptosis, which...

The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway.

Exp. Cell Res. 327(2) , 264-75, (2014)

Hispidin, a phenolic compound from Phellinus linteus (a medicinal mushroom), has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties. However, the cardi...