GMP disodium salt

Names

[ Name ]:
GMP disodium salt

[Synonym ]:
Sodium Guanylate
MFCD00070575
Disodium 2-amino-9-(5-O-phosphonato-β-D-ribofuranosyl)-9H-purin-6-ol
2'(3')-GMP
GMP
GMP disodium salt
5'-GMP disodium salt
Guanosine 5'-monophosphate disodium salt
Na2(5'-GMP)
5'-guanosine monophosphate disodium salt
sodiumgmp
EINECS 226-914-1
Disodium 5'-guanylate
5'-GMP-NA2
Disodium guanosine 5'-monophosphate
5'-Guanylic acid, sodium salt (1:2)
9H-purin-6-ol, 2-amino-9-(5-O-phosphono-β-D-ribofuranosyl)-, sodium salt (1:2)
5'-GMP 2NA
disodiumgmp
5'-Guanylic acid disodium salt
Disodium 5'-O-phosphonatoguanosine
GMP-5
GMP-2Na
FEMA 3668

Biological Activity

[Description]:

5'-Guanylic acid disodium salt (5'-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes[1].

[Related Catalog]:

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Lan T, et al. Type II cGMP-dependent protein kinase phosphorylates EGFR at threonine 669 and thereby inhibits its activation. Biochem Biophys Res Commun. 2019 Aug 6.

Chemical & Physical Properties

[ Boiling Point ]:
890.2ºC at 760 mmHg

[ Melting Point ]:
300°C

[ Molecular Formula ]:
C₁₀H₁₂N₅Na₂O₈P

[ Molecular Weight ]:
407.184

[ Flash Point ]:
492.2ºC

[ Exact Mass ]:
407.021881

[ PSA ]:
221.51000

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
>50 g/L

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF9290000

CHEMICAL NAME :: 5'-Guanylic acid, disodium salt

CAS REGISTRY NUMBER :: 5550-12-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C10-H12-N5-O8-P.2Na

MOLECULAR WEIGHT :: 407.22

WISWESSER LINE NOTATION :: T56 BN DN FN HNVJ GZ D- BT5OTJ CQ DQ E1OPO&O&O &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >17300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3880 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2720 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5010 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5050 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3580 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 1 gm/L

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1092 No. of Facilities: 177 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 1410 (estimated) No. of Female Employees: 33 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
MF9290000

[ HS Code ]:
29349990

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29349990

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