[Nle13]-Motilin

Names

[ CAS No. ]:
55524-56-6

[ Name ]:
[Nle13]-Motilin

Biological Activity

[Description]:

[Nle13]-Motilin, a motilin analogue, is a motilin receptor agonist[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Motilin Receptor

Research Areas >> Neurological Disease

[In Vitro]

[Nle13]-Motilin (0.1-30 nM, 15 min) increases the amplitude of electrically-evoked, neuronally-mediated contractions in the isolated gastric antrum[1]. [Nle13]-Motilin (0.3 μM, 10 min) induces a moderate increase in spontaneous contractility in the stomach[2].

[References]

[1]. Dass NB, et al. The rabbit motilin receptor: molecular characterisation and pharmacology. Br J Pharmacol. 2003 Nov;140(5):948-54.

[2]. Venkova K, et al. Effect of TZP-201, a novel motilin receptor antagonist, in the colon of the musk shrew (Suncus murinus). J Pharm Pharmacol. 2009 Mar;61(3):367-73.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂₁H₁₉₀N₃₄O₃₅

[ Molecular Weight ]:
2681.01

[Nle13]-Motilin

Names

Biological Activity

Chemical & Physical Properties

Related Compounds