Magnesium stearate

Names

[ CAS No. ]:
557-04-0

[ Name ]:
Magnesium stearate

[Synonym ]:
MAGNESIUM DISTEARATE
Magnesium stearate
synpro 90
MFCD00036391
Stearic acid, magnesium salt
MAGNESIUM STEARATE (E-470B, F.C.C.) ADITIO
EINECS 209-150-3
Octadecanoic acid, magnesium salt
stearic acid magnesium salt
Octadecanoic acid, magnesium salt (2:1)
stearatedemagnesium
MAGENSIUM STEARATE
MAGNESIUMSTEARATE
MEGNESIUM STEATATE
MAGNESIUMSTEARATEBP
Magnesium dioctadecanoate
Microcrystalline cellulose use as the oral steroid filler
Dibasic magnesium stearate
MAGNESIUM STEARATE API
magnesiumdistearate
Synpro Magnesium Stearate 90
OCTADECANOIC ACID MAGNESIUM SALT
stearate magnesium
Magnesiumdistearat
MAGNESIUM STEARATE NF
MAGNESIUM OCTADECANOATE
magnesium sterate
stearic acid,magnesium stearate
Dolomol
Magnesiumstearat
OCTADECANOICACID, MAGNESIUM SALT (2:1)
MAGNESIUMSTEARATE,FCC
petracmg20nf
MAGNESIUM STEARATE, FCC
Magnesium Stearate Bp

Biological Activity

[Description]:

Magnesium stearate is a commonly used pharmaceutical lubricant. But Magnesium stearate leads to an adverse effect on bonding between particles. Magnesium stearate can be used as an excipient, such as lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Zuurman K, et al. Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties[J]. International journal of pharmaceutics, 1999, 179(1): 107-115.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Chemical & Physical Properties

[ Density]:
1.028g/cm3

[ Boiling Point ]:
359.4ºC at 760mmHg

[ Melting Point ]:
200 °C(lit.)

[ Molecular Formula ]:
C₃₆H₇₀MgO₄

[ Molecular Weight ]:
591.24

[ Flash Point ]:
162.4ºC

[ Exact Mass ]:
590.512451

[ PSA ]:
52.60000

[ LogP ]:
12.50830

[ Index of Refraction ]:
1.45 (25ºC)

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
Insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WI4390000

CHEMICAL NAME :: Stearic acid, magnesium salt

CAS REGISTRY NUMBER :: 557-04-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C36-H70-O4.Mg

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1092 gm/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 17,51,1980 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81884 No. of Facilities: 2092 (estimated) No. of Industries: 19 No. of Occupations: 34 No. of Employees: 31116 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6914 No. of Facilities: 64 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 320 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81884 No. of Facilities: 5057 (estimated) No. of Industries: 57 No. of Occupations: 78 No. of Employees: 184994 (estimated) No. of Female Employees: 101129 (estimated)

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
-

[ RTECS ]:
WI4390000

[ HS Code ]:
29157030

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29157030

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