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Crocin II

Names

[ CAS No. ]:
55750-84-0

[ Name ]:
Crocin II

[Synonym ]:
Tricrocin
glucopyranosyl ester
(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate (non-preferred name)
Crocetingentiobiosylglucosyl ester
trans-crocin-2
Crocin 2
Crocin B
CrocinII
Crocin II

Biological Activity

[Description]:

Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity.Crocin II inhibits NO production with an IC50 value of 31.1 μM.Crocin II suppresses the expressions of protein and m-RNA of iNOS and COX-2[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX
Research Areas >> Neurological Disease

[Target]

IC50: 31.3 μM (NO production)[1]


[References]

[1]. Hong YJ, et al. Anti-inflammatory activities of crocetin derivatives from processed Gardenia jasminoides. Arch Pharm Res. 2013 Aug;36(8):933-40.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
1032.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C38H54O19

[ Molecular Weight ]:
814.824

[ Flash Point ]:
309.8±27.8 °C

[ Exact Mass ]:
814.325928

[ PSA ]:
312.05000

[ LogP ]:
1.64

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.636

Safety Information

[ HS Code ]:
29389090

Related Compounds