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Pentanamide,N-(aminocarbonyl)-2-ethyl-3-methyl-

Names

[ CAS No. ]:
5579-13-5

[ Name ]:
Pentanamide,N-(aminocarbonyl)-2-ethyl-3-methyl-

[Synonym ]:
CAPURIDE
McN-X-94
2-Ethyl-3-methylpentanoyl-harnstoff
1-(2-ethyl-3-methyl-pentanoyl)-urea
(2-ethyl-3-methyl-valeryl)-urea
Pacinox
(Ethyl-sec-butylacetyl)urea
(2-Aethyl-3-methyl-valeryl)-harnstoff
mcn-x 9
Capurid
sec.Butylethylacetylharnstoff

Biological Activity

[Description]:

Capuride is an orally active sedative agent. Capuride has anticonvulsant activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vivo]

Capuride (VPA, 38-107 mg/kg p.o.) shows anticonvulsant activity in MES and scMet induced seizures rats[2]. Capuride (p.o., rats) shows neurotoxicity with an ED50 of 232 mg/kg[2]. Capuride (49-71 mg/kg, i.p.) shows anticonvulsant activity in 6 Hz Psychomotor seizure mice[2]. Animal Model: Electrically (MES) and chemically (scMet) induced seizures in rats[2] Dosage: 38-107 mg/kg Administration: Oral administration (p.o.) Result: ED50s: 54 mg/kg (MES model), 77 mg/kg (scMet model).

Chemical & Physical Properties

[ Density]:
1.009g/cm3

[ Molecular Formula ]:
C9H18N2O2

[ Molecular Weight ]:
186.25100

[ Exact Mass ]:
186.13700

[ PSA ]:
72.19000

[ LogP ]:
2.34480

[ Index of Refraction ]:
1.463

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds