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4-Hydroxyderricin

Names

[ CAS No. ]:
55912-03-3

[ Name ]:
4-Hydroxyderricin

[Synonym ]:
HMS2195D24
4-Hydroxydervicin
4-hydroxyionchocarpin
4-Hydroxyderricin

Biological Activity

[Description]:

4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is a potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC50 of 3.43 μM. 4-Hydroxyderricin also mildly inhibits DBH (dopamine β-hydroxylase) activity. 4-Hydroxyderricin has antidepressant activity[1].

[Target]

IC50: 3.43 μM (MAO-B)[1]


[References]

[1]. Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul). 2013 May 30;21(3):234-40.

Chemical & Physical Properties

[ Density]:
1.181g/cm3

[ Boiling Point ]:
542ºC at 760mmHg

[ Melting Point ]:
136-137℃

[ Molecular Formula ]:
C21H22O4

[ Molecular Weight ]:
338.39700

[ Flash Point ]:
190.8ºC

[ Exact Mass ]:
338.15200

[ PSA ]:
66.76000

[ LogP ]:
4.51120

[ Index of Refraction ]:
1.622

[ Storage condition ]:
2-8℃

Related Compounds