ARC 239 dihydrochloride

Names

[ Name ]:
ARC 239 dihydrochloride

[Synonym ]:
Pertussis Toxin

Biological Activity

[Description]:

ARC 239 dihydrochloride is a selective α2B/2C adrenoceptor antagonist (pKd values are 5.95, 7.41 and 7.56 at α2A, α2B, and α2C receptors respectively). ARC 239 dihydrochloride binds to CHO cell membranes expressing human recombinant a2A-, a2B- or a2C-adrenoceptor subtypes with pKis of 5.6, 8.4, and 7.08, respectively[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Inflammation/Immunology

[Target]

Alpha-2B adrenergic receptor

5-HT1A Receptor

[References]

[1]. M R Corboz, et al. Pharmacological characterization of alpha 2-adrenoceptor-mediated responses in pig nasal mucosa. Auton Autacoid Pharmacol. 2003 Aug;23(4):208-19.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₁Cl₂N₃O₃

[ Molecular Weight ]:
480.42700

[ Exact Mass ]:
479.17400

[ PSA ]:
53.09000

[ LogP ]:
4.32220

ARC 239 dihydrochloride

Names

Biological Activity

Chemical & Physical Properties

Related Compounds