MAGNESIUM L-ASPARTATE

Names

[ Name ]:
MAGNESIUM L-ASPARTATE

[Synonym ]:
ASPARTIC ACID MAGNESIUM SALT
Magnesium (2S)-2-aminosuccinate
L-ASPARTATE SODIUM
H-ASP-ONA
L-ASPARTIC ACID MAGNESIUM SALT
asparginic acid disodium salt
Natriumasparaginat
L-Aspartic acid, magnesium salt (1:1)
sodium polyaspartate
H-ASP-OH NA
MonosodiumL-aspartate
aspartic acid disodium salt
L-Aspartic acid, magnesium salt (2:1)
sodium aspartate
aspartatemonosodiumsalt
monosodiumaspartate
Sodium L-aspartic acid

Biological Activity

[Description]:

L-Aspartic acid disodium is an amino acid, can be used as a suitable prodrug for colon-specific drug deliverly[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

Microbial Metabolite

Human Endogenous Metabolite

[References]

[1]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11.

[2]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406.

Chemical & Physical Properties

[ Density]:
1.514g/cm3

[ Boiling Point ]:
264.1ºC at 760mmHg

[ Melting Point ]:
270-271ºC

[ Molecular Formula ]:
C₄H₅MgNO₄

[ Molecular Weight ]:
155.392

[ Flash Point ]:
113.5ºC

[ Exact Mass ]:
155.006897

[ PSA ]:
78.62000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CI9450400

CHEMICAL NAME :: Aspartic acid, disodium salt, L-

CAS REGISTRY NUMBER :: 5598-53-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H5-N-O4.2Na

MOLECULAR WEIGHT :: 177.08

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 62,203,1990 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 500 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2 gm/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 500 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2 gm/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984

Safety Information

[ Hazard Codes ]:
Xi