2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE

Names

[ Name ]:
2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE

[Synonym ]:
5-O-Methylembelin
2-hydroxy-5-methoxy-3-undecylcyclohexa-2,5-diene-1,4-dione

Biological Activity

[Description]:

5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, low-density lipoprotein receptor (IDOL), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Cardiovascular Disease

[In Vitro]

5-O-Methylembelin（compound 3；20 μM；24 小时）显着下调 PCSK9（IC50 值为 4.9 μM）、IDOL 和 SREBP2 mRNA 表达[1]。 RT-PCR[1] Cell Line: HepG2 cells Concentration: 20 μM Incubation Time: 24 h Result: Inhibited PCSK9, IDOL, and SREBP2 mRNA expression.

[References]

[1]. Pisey Pel, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega. 2022 Dec 8;7(50):47296-47305.

Chemical & Physical Properties

[ Density]:
1.06g/cm3

[ Boiling Point ]:
439.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₂₈O₄

[ Molecular Weight ]:
308.41300

[ Flash Point ]:
149.9ºC

[ Exact Mass ]:
308.19900

[ PSA ]:
63.60000

[ LogP ]:
4.40150

[ Index of Refraction ]:
1.505

Safety Information

[ HS Code ]:
2914690090

Customs

[ HS Code ]: 2914690090

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%