MK196

Names

[ Name ]:
MK196

[Synonym ]:
(6,7-Dichloro-2-methyl-1-oxo-2-phenyl-indan-5-yloxy)-acetic acid
<(6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyl)oxy>acetic acid
indacrinone
(1-oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy) acetic acid
[(6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyl)-oxy]-acetic acid
(1-oxo-2-phenyl-2-methyl-6,7-dichloro-5-indanyloxy)-acetic acid
(6,7 dichloro 2 methyl 1 oxo 2 phenylindan 5 yloxy)acetic acid
[(6,7-Dichloro-2,3-Dihydro-2-Methyl-1-Oxo-2-Phenyl-1H-Inden-5-Yl)Oxy]Acetic Acid
MK196

Biological Activity

[Description]:

MK196 (MK-196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vivo]

As the dose increasing from 1 to 10 mg/kg, the amount excreted via the urine decreased from 20 to 11% of administered dose. The amount excretes via the feces is 2-fold higher at the lower dose. At the 10 mg/kg dose the MK-196/1 ratio was 0.8 and 5 for the urine and feces, respectively. The urinary ratio of MK-196/1 decrease as dose increasing from 10 mg/kg (0.5) to 20 mg/kg (0.2)[1].

[Animal admin]

Sixteen mice are administered MK-196-14C. Four mice, 2 male and 2 female, are dosed orally with 10 mg/kg of drug and four additional mice (2M, 2F) are given the drug i.v. via the tail vein. In similar fashion eight additional mice are dosed with 1 mg/kg MK-196-14C either orally or intravenously.The animals are housed in separate metabolism cages, 2 mice of same sex per cage.The animals are fasted overnight prior to drug administration. Urine and feces are collected for the 24-hour period post drug. Animals are allowed free access to water. Urine specimens are also obtained from mice which receive MK-196 orally at doses of 10 and 20 mg/kg/day for 9 days. On day 9 the mice are dosed and placed in metabolism cages; two cages are used per sex per group. Urine is collected during the five-hour period post last dose. A total of nineteen mice are dosed with 10 mg/kg and 18 mice are dosed with 20 mg/kg of drug[1].

[References]

[1]. A.G. ZACCHEI, et al. THE PHYSIOLOGICAL DISPOSITION

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.423g/cm3

[ Boiling Point ]:
553.63°C at 760 mmH

[ Molecular Formula ]:
C₁₈H₁₄Cl₂O₄

[ Molecular Weight ]:
365.20700

[ Flash Point ]:
288.625°C

[ Exact Mass ]:
364.02700

[ PSA ]:
63.60000

[ LogP ]:
4.15350