PRIMA-1
Names
[ CAS No. ]:
5608-24-2
[ Name ]:
PRIMA-1
[Synonym ]:
Tocris-1862
1-Azabicyclo[2.2.2]octan-3-one, 2,2-bis(hydroxymethyl)-
prima-1
2,2-Bis(hydroxymethyl)quinuclidin-3-one
2,2-Bis-methylol-3-chinuclidinon
MFCD04974196
p53 Reactivation and Induction of Massive Apoptosis
2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Biological Activity
[Description]:
[Related Catalog]:
[Target]
p53[1]
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
353.7±17.0 °C at 760 mmHg
[ Molecular Formula ]:
C9H15NO3
[ Molecular Weight ]:
185.220
[ Flash Point ]:
167.7±20.9 °C
[ Exact Mass ]:
185.105194
[ PSA ]:
60.77000
[ LogP ]:
0.70
[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C
[ Index of Refraction ]:
1.582
[ Storage condition ]:
-20℃
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H334
[ Precautionary Statements ]:
P261-P342 + P311
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R22;R43
[ Safety Phrases ]:
S36-S37
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Leuk. Lymphoma 56(3) , 739-47, (2015)
The tumor suppressor p53 is often mutated in human cancers. Restoring its antitumor activity has been shown to be a promising therapeutic approach for cancer treatment. Here we analyzed the activity a...
3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.Mol. Cancer 14 , 135, (2015)
Urinary bladder cancer is one of the most fatal and expensive diseases of industrialized world. Despite the strenuous efforts, no seminal advances have been achieved for its clinical management. Given...
The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells.Oncotarget 5(21) , 10678-91, (2014)
The p53 tumor suppressor protein plays a crucial role in influencing cell fate decisions in response to cellular stress. As p53 elicits cell cycle arrest, senescence or apoptosis, the integrity of the...