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5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylamide

Names

[ CAS No. ]:
56290-94-9

[ Name ]:
5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylamide

[Synonym ]:
RMI 81,968
MEDROXALOL
EINECS 260-099-3
Medroxalolum

Biological Activity

[Description]:

Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[In Vitro]

Medroxalol (0.1-10 μM; 20 min) shows α- and β-adrenergic receptor antagonism in isolated rabbit aortic strip[1]. Cell Viability Assay[1] Cell Line: Isolated rabbit aortic strip Concentration: 0.1-10 μM Incubation Time: 20 min Result: Showed pA2 values of 6.09 and 7.73 for α-adrenergic receptors and β-adrenergic receptors, respevtively.

[In Vivo]

Medroxalol (oral gavage; 12.5-50 mg/kg; once daily; 12 d) treatment shows antihypertensive activity in spontaneously hypertensive rats[1]. Animal Model: Male spontaneously hypertensive rats (SHR)[1] Dosage: 12.5, 25, or 50 mg/kg Administration: Oral gavage; 12.5, 25, or 50 mg/kg; once daily; 12 days Result: Produced a dose-related fall in blood pressure.

Chemical & Physical Properties

[ Density]:
1.307g/cm3

[ Boiling Point ]:
604.1ºC at 760 mmHg

[ Molecular Formula ]:
C20H24N2O5

[ Molecular Weight ]:
372.41500

[ Flash Point ]:
319.1ºC

[ Exact Mass ]:
372.16900

[ PSA ]:
114.04000

[ LogP ]:
2.95530

[ Index of Refraction ]:
1.626

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds