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Terminolic acid

Names

[ CAS No. ]:
564-13-6

[ Name ]:
Terminolic acid

[Synonym ]:
Olean-12-en-28-oic acid,2,3,6,23-tetrahydroxy-,(2alpha,3beta,4alpha,6beta)
2,3,6,23-Tetrahydroxyolean-12-en-28-oic acid (2alpha,3beta,4alpha,6beta)
Terminolic acid

Biological Activity

[Description]:

Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity[1][1].

[Related Catalog]:

Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Gossan DPA, et, al. Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum. Fitoterapia. 2016 Apr;110:89-95.

[2]. Legiawati L, et, al. In silico study of Centella asiatica active compounds as anti-inflammatory agent by decreasing Il-1 and Il-6 activity, promoting Il-4 activity. /J. Pharm. Sci. & Res. Vol. 10(9), 2018, 2142-2147.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H48O6

[ Molecular Weight ]:
504.69900

[ Exact Mass ]:
504.34500

[ PSA ]:
118.22000

[ LogP ]:
4.14760

Related Compounds