Glutaurine

Glutaurine containing glutamine and taurine residues is an orally active hormone of the parathyroid. Glutaurine, as a hormone, is isolated from parathyroid gland oxyphil cells. Glutaurine can be used for the research of antiepileptic and anti-amnesia[1][2][3][4].

Signaling Pathways >> Others >> Thyroid Hormone Receptor

Research Areas >> Neurological Disease

Glutaurine (1, 10, 20 or 50 μg/rat; p.o.) significantly restores the latency of entry in both the 24 and 48 hours tests at the dose of 50 μg/rat[2]. Glutaurine (100~3000 ug/kg; i.p.) significantly reduces T3 blood levels in a dose-dependent manner, but does not significantly raise T4 blood levels[3]. Animal Model: CFY male rats (170~250g)[2] Dosage: 1, 10, 20 or 50 μg/rat Administration: P.o. Result: Significantly restored the latency of entry in both the 24 and 48 h tests at the dose of 50 μg/rat. Animal Model: Fischer 344 rats[3] Dosage: 100~3000 ug/kg Administration: I.p. Result: Significantly reduced T3 blood levels in a dose-dependent manner, but did not significantly raise T4 blood levels.

[1]. Balázs M, et al. Effects of glutaurine treatment on electroshock-induced amnesia. Antiamnesic action of glutaurine. Neuropeptides. 1988;12(2):55-58.

[2]. Feuer L, et al. Effect of glutaurine, a newly discovered parathyroid hormone on rat thymus cultures. Acta Morphol Acad Sci Hung. 1978;26(2):87-94.

[3]. Baskin S, et al. The effect of glutaurine on thyroid hormones in the rat. Neuropeptides. 1987;9(1):45-50.

[4]. Uemura S, et al. Gamma-glutamyltaurine has potent and long-lasting antiepileptic action as demonstrated by intra-amygdaloid injection in amygdala-kindled rats. Brain Res. 1992;594(2):347-350.

MOLECULAR FORMULA :

C7-H14-N2-O6-S

MOLECULAR WEIGHT :

254.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,110,1984