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Cyclo(Pro-Leu)

Names

[ CAS No. ]:
5654-86-4

[ Name ]:
Cyclo(Pro-Leu)

Biological Activity

[Description]:

Cyclo(Pro-Leu) (A 65190) is an active metabolite. Cyclo(Pro-Leu) can be isolated from Streptomyces sp. BM8. Cyclo(Pro-Leu) can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Microbial Metabolite


[In Vitro]

Cyclo(Pro-Leu) (compound 7) (1.23 μg/mL-300 μg/mL; 48 h) has cytotoxic activity for HT-29, MCF-7, A375, K562, and NCM460 cell lines with IC50 values of 101.56 μM, 78.78 μM, 51.13 μM, 21.72 μM and 775.86 μM, respectively[1].

[References]

[1]. Shengsheng Lu, et al. Secondary Metabolites with Cytotoxic Activities from Streptomyces sp. BM-8 Isolated from the Feces of Equusquagga. Molecules. 2021 Dec 13;26(24):7556.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H18N2O2

[ Molecular Weight ]:
210.27

[ Storage condition ]:
-20°C

Related Compounds