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BMS 566419

Names

[ CAS No. ]:
566161-24-8

[ Name ]:
BMS 566419

[Synonym ]:
unii-9688e11zq0

Biological Activity

[Description]:

BMS-566419 is an acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH). Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo synthesis of guanosine nucleotides. BMS-566419 has clinical utility for the research of transplant rejection[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Watterson SH, et al. Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J Med Chem. 2007;50(15):3730-3742.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H30FN5O2

[ Molecular Weight ]:
487.56900

[ Exact Mass ]:
487.23800

[ PSA ]:
84.82000

[ LogP ]:
4.60010

Related Compounds