Nifenalol

Names

[ Name ]:
Nifenalol

[Synonym ]:
INPEA hydrochloride
N-isopropyl-p-nitrophenylethanolamine hydrochloride
Nifenalol

Biological Activity

[Description]:

Nifenalol hydrochloride is a β-adrenergic receptor antagonist. Nifenalol hydrochloride induces the Early Afterdepolarization (EAD) effect. EAD is a phenomenon in cardiac electrophysiology that usually occurs during an action potential in ventricular muscle cells and can lead to arrhythmia. The EAD effect of Nifenalol hydrochloride can be blocked by Tetrodotoxin. Nifenalol hydrochloride is used in the study of conditions such as irregular heartbeat or high blood pressure[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

β-adrenoceptor

[References]

[1]. Lemmens-Gruber R, et al. Arrhythmogenic effect of beta-adrenoceptor-blocking drugs in Purkinje fibres of guinea-pig hearts. Arch Int Pharmacodyn Ther. 1996 Jan-Feb;331(1):46-58.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₇ClN₂O₃

[ Molecular Weight ]:
260.72

[ Exact Mass ]:
260.09300

[ PSA ]:
78.08000

[ LogP ]:
3.34230

Safety Information

[ HS Code ]:
2922199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%