4-Methyl-L-leucine

Names

[ Name ]:
4-Methyl-L-leucine

[Synonym ]:
Glycine, N-(2,2-dimethylpropyl)-
4-Methyl-L-leucine
MFCD00066079
2(S)-amino-4,4-dimethylpentanoic acid
Neopentylglycine
L-Leucine, 4-methyl-
3-tert-Butyl-L-alanine
N-(2,2-Dimethylpropyl)glycine
L-neopentylglycine
4-METHYL-LEUCINE
(S)-2-amino-4,4-dimethyl-pentanoic acid

Biological Activity

[Description]:

4-Methyl-L-leucine is a Glycine (HY-Y0966) derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
226.1±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₁₅NO₂

[ Molecular Weight ]:
145.199

[ Flash Point ]:
90.6±22.6 °C

[ Exact Mass ]:
145.110275

[ PSA ]:
63.32000

[ LogP ]:
0.97

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.449

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

The specificity and kinetic mechanism of branched-chain amino acid aminotransferase from Escherichia coli studied with a new improved coupled assay procedure and the enzyme's potential for biocatalysis.

FEBS J. 281(1) , 391-400, (2014)

Branched-chain amino acid aminotransferase (BCAT) plays a key role in the biosynthesis of hydrophobic amino acids (such as leucine, isoleucine and valine), and its substrate spectrum has not been full...

Synthesis of gamma-methyl-L-leucine (neopentylglycine, Neo) and derivatives suitable for peptide synthesis.

Int. J. Pept. Protein Res. 18 , 249, (1981)

The modified Strecker synthesis of Patel & Worsley was combined with an enzymatic deamidation in the final step, to produce the title compound. The amino acid is a member of the family of the "fat" am...