Vitamin K4

Names

[ CAS No. ]:
573-20-6

[ Name ]:
Vitamin K4

[Synonym ]:
2-Methyl-1,4-naphthalenediol Diacetate
MFCD00021469
2-Methyl-1,4-naphthalenediyl diacetate
(4-acetyloxy-3-methylnaphthalen-1-yl) acetate
1,4-Naphthalenediol, 2-methyl-, diacetate
Kappaxan (VAN)
2-Methylnaphthalene-1,4-diyl diacetate
EINECS 209-352-1
Vitamin K4

Biological Activity

[Description]:

Vitamin K4 is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

[References]

[1]. Jiang Y, et al. Vitamin K4 induces tumor cytotoxicity in human prostate carcinoma PC-3 cells via the mitochondria-related apoptotic pathway. Pharmazie. 2013 Jun;68(6):442-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
388.9±30.0 °C at 760 mmHg

[ Melting Point ]:
113 °C

[ Molecular Formula ]:
C₁₅H₁₄O₄

[ Molecular Weight ]:
258.269

[ Flash Point ]:
195.1±23.0 °C

[ Exact Mass ]:
258.089203

[ PSA ]:
52.60000

[ LogP ]:
2.67

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.580

[ Storage condition ]:
2~8 ℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ5250000

CHEMICAL NAME :: 1,4-Naphthalenediol, 2-methyl-, diacetate

CAS REGISTRY NUMBER :: 573-20-6

BEILSTEIN REFERENCE NO. :: 1991457

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H14-O4

MOLECULAR WEIGHT :: 258.29

WISWESSER LINE NOTATION :: L66J BOV1 C1 EOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 75,111,1942

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338 + P310

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
QJ5250000

Precursor & DownStream

Precursor

DownStream

Articles

Vitamin K4 induces tumor cytotoxicity in human prostate carcinoma PC-3 cells via the mitochondria-related apoptotic pathway. Jiang Y, et.al.

Pharmazie 68 , 442-448, (2013)

One-Pot Hydroacetylation of Menadione (Vitamin K3) to Menadiol Diacetate (Vitamin K4) by Heterogeneous Catalysis. Dobrinescu C, et.al.

Adv. Synth. Catal. 354 , 1301-1306, (2012)