Aureothricin

Names

[ CAS No. ]:
574-95-8

[ Name ]:
Aureothricin

[Synonym ]:
propionopyrrothine
Aureothricin
Anzeothricin
4-methyl-6-propionylamino-4H-[1,2]dithiolo[4,3-b]pyrrol-5-one
N-(4-methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)-propionamide
N-(4-Methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)-propionamid
Farcinicin
Propiopyvothine
Aurethricin

Biological Activity

[Description]:

Aureothricin is a dithiolopyrrolone (DTP) antibiotic first isolated from Streptomyces and exhibits relatively broad-spectrum antibiotic activity. Aureothricin can inhibit adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Bacteral[1]

[References]

[1]. Li B, et al. Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics. Nat Prod Rep. 2014 Jul;31(7):905-23.

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Boiling Point ]:
479.1ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₁₀N₂O₂S₂

[ Molecular Weight ]:
242.31800

[ Flash Point ]:
243.6ºC

[ Exact Mass ]:
242.01800

[ PSA ]:
111.07000

[ LogP ]:
2.61110

[ Index of Refraction ]:
1.694