Tos-PEG8-Tos

Names

[ Name ]:
Tos-PEG8-Tos

[Synonym ]:
1,24-bis(tosyloxy)-3,6,9,12,15,18,21-heptaoxatetracosane
Octaethylene glycol di(p-toluenesulfonate)
Octaethylene glycol ditosylate
3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diyl bis(4-methylbenzenesulfonate)
1,23-bis(tosyloxy)-3,6,9,12,15,18,21-heptaoxatricosane

Biological Activity

[Description]:

Tos-PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₄₆O₁₃S₂

[ Molecular Weight ]:
678.80800

[ Exact Mass ]:
678.23800

[ PSA ]:
168.11000

[ LogP ]:
4.69200

Tos-PEG8-Tos

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds