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Substance P(1-4)

Names

[ CAS No. ]:
57468-16-3

[ Name ]:
Substance P(1-4)

[Synonym ]:
Arg-Pro-Lys-Pro
1-(6-amino-2-{[1-(2-amino-5-carbamimidamidopentanoyl)pyrrolidin-2-yl]formamido}hexanoyl)pyrrolidine-2-carboxylic acid
substance P(1-4)
SUBSTANCE P,Fragment 1-4

Biological Activity

[Description]:

Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Substance P(1-4) (0.1 nM-1 μM) inhibits endogenous erythroid colony (EEC) formation in PV bone marrow cultures[1]. Substance P(1-4) (0.1 nM-1 μM; CD36+/GpA- cells) decreases of erythroid colony numbers of 47% and inhibits proliferation of PV CD36+/GpA- cells of 30 %[1]. Cell Viability Assay[1] Cell Line: PV CD36+/GpA- cells Concentration: 0.1 nM-1 μM Incubation Time: 2 days Result: Inhibited proliferation of PV CD36+/GpA- cells of 30 %. Apoptosis Analysis[1] Cell Line: PV CD36+/GpA- cells Concentration: 10 nM Incubation Time: 2 days Result: Increased the percentage of cell death of 27.3%.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H40N8O5

[ Molecular Weight ]:
496.60400

[ Exact Mass ]:
496.31200

[ PSA ]:
220.96000

[ LogP ]:
1.11560

Related Compounds