mannomustine
Names
[ CAS No. ]:
576-68-1
[ Name ]:
mannomustine
[Synonym ]:
Mannit-lost [German]
Mannomustin
Mannitol nitrogen mustard
Manomustina [INN-Spanish]
Mannomustine [INN:BAN:DCF]
Mannit-mustard [German]
Mannit-Lost
Mannomustinum [INN-Latin]
1,6-Bis-<(2-chlorethyl)-amino>-1,6-dideoxy-D-mannitol
1,6-Bis-(2-chlor-aethylamino)-1,6-didesoxy-D-mannit
BCM (cytostatic)
mannomustine
1,6-bis-(2-chloro-ethylamino)-1,6-dideoxy-D-mannitol
1,6-Bis-<2-chlor-ethylamino>-1,6-didesoxy-D-mannit
Chemical & Physical Properties
[ Density]:
1.353g/cm3
[ Boiling Point ]:
541.9ºC at 760 mmHg
[ Melting Point ]:
278°C (rough estimate)
[ Molecular Formula ]:
C10H22Cl2N2O4
[ Molecular Weight ]:
305.19900
[ Flash Point ]:
281.5ºC
[ Exact Mass ]:
304.09600
[ PSA ]:
104.98000
[ Index of Refraction ]:
1.544
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OP2100000
- CHEMICAL NAME :
- Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-, D-,
- CAS REGISTRY NUMBER :
- 576-68-1
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C10-H22-Cl2-N2-O4
- MOLECULAR WEIGHT :
- 305.24
- WISWESSER LINE NOTATION :
- G2M1YQYQYQYQ1M2G -D
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Blood - leukopenia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Cells - not otherwise specified
- DOSE/DURATION :
- 2900 nmol/L
- REFERENCE :
- SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 18,210,1982