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Bromo-PEG3-alcohol

Names

[ CAS No. ]:
57641-67-5

[ Name ]:
Bromo-PEG3-alcohol

[Synonym ]:
2-[2-(2-Brom-aethoxy)-aethoxy]-aethanol
2-(2-(2-bromoethoxy)ethoxy)ethanol
Diaethylenglykol-mono-(2-brom-aethylaether)
Bromo-PEG3-alcohol

Biological Activity

[Description]:

Br-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.411±0.06 g/cm3

[ Boiling Point ]:
276.3±20.0 °C

[ Molecular Formula ]:
C6H13BrO3

[ Molecular Weight ]:
213.07000

[ Exact Mass ]:
212.00500

[ PSA ]:
38.69000

[ LogP ]:
0.40680

Safety Information

[ Hazard Codes ]:
T+

Related Compounds