(S)-2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-2,3-dihydro-8-hydroxy-4H-1-benzopyran-4-one

Names

[ CAS No. ]:
577-38-8

[ Name ]:
(S)-2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-2,3-dihydro-8-hydroxy-4H-1-benzopyran-4-one

[Synonym ]:
isookanin-7-o-glucoside
7-o-glucosyl-4',5',8-trihydroxyflavanone
isookanin-7-glucoside
3',4',7,8-tetrahydroxyflavanone-7-o-glucoside
trihydroxyflavanone

Biological Activity

[Description]:

Flavanomarein is a predominant flavonoid of Coreopsis tinctoria Nutt with protective effects against diabetic nephropathy. Flavanomarein has good antioxidative, antidiabetic, antihypertensive and anti-hyperlipidemic activities[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Nan-Nan Zhang, et al. Flavanomarein inhibits high glucose-stimulated epithelial-mesenchymal transition in HK-2 cells via targeting spleen tyrosine kinase. Sci Rep. 2020 Jan 16;10(1):439.

[2]. Liang Le, et al. The protective effects of the native flavanone flavanomarein on neuronal cells damaged by 6-OHDA. Phytomedicine. 2019 Feb;53:193-204.

Chemical & Physical Properties

[ Density]:
1.665g/cm3

[ Boiling Point ]:
818.2ºC at 760 mmHg

[ Melting Point ]:
243-246ºC

[ Molecular Formula ]:
C₂₁H₂₂O₁₁

[ Molecular Weight ]:
450.39300

[ Flash Point ]:
288.9ºC

[ Exact Mass ]:
450.11600

[ PSA ]:
186.37000

[ Index of Refraction ]:
1.712

Safety Information

[ Hazard Codes ]:
Xi