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Diloxanide

Names

[ CAS No. ]:
579-38-4

[ Name ]:
Diloxanide

[Synonym ]:
Diloxanid
Amebamida
EINECS 209-439-4
Diloxanide
RD 3803
Acetamide,2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl
Diloxanidum [INN-Latin]
Entamide
Ame-boots
Diloxanida [INN-Spanish]

Biological Activity

[Description]:

Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147)[1].

[Related Catalog]:

Research Areas >> Infection

[In Vivo]

Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate[1]. Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats[2].

[References]

[1]. DB08792

[2]. D K Chatterjee, et al. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res. 1987;74(1):30-3.

Chemical & Physical Properties

[ Density]:
1.439g/cm3

[ Boiling Point ]:
356.2ºC at 760 mmHg

[ Melting Point ]:
175°

[ Molecular Formula ]:
C9H9Cl2NO2

[ Molecular Weight ]:
234.07900

[ Flash Point ]:
169.2ºC

[ Exact Mass ]:
233.00100

[ PSA ]:
40.54000

[ LogP ]:
2.15870

[ Index of Refraction ]:
1.615

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AE1970600
CHEMICAL NAME :
Acetanilide, 2,2-dichloro-4'-hydroxy-N-methyl-
CAS REGISTRY NUMBER :
579-38-4
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H9-Cl2-N-O2
MOLECULAR WEIGHT :
234.09

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>12500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,128,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,128,1962

Precursor & DownStream

Precursor

DownStream

Related Compounds