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3'-Deoxy-3'-fluorouridine

Names

[ CAS No. ]:
57944-13-5

[ Name ]:
3'-Deoxy-3'-fluorouridine

[Synonym ]:
1-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)uracil
3'-Deoxy-3'-fluorouridine
3'-Fluoro-3'-deoxyuridine
Uridine,3'-deoxy-3'-fluoro
Uridine, 3'-deoxy-3'-fluoro-

Biological Activity

[Description]:

3′-Deoxy-3′-fluorouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C9H11FN2O5

[ Molecular Weight ]:
246.19

[ Exact Mass ]:
246.065201

[ PSA ]:
104.81000

[ LogP ]:
-1.18

[ Index of Refraction ]:
1.608

Related Compounds