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9-[3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-3H-purin-6-one

Names

[ CAS No. ]:
58004-19-6

[ Name ]:
9-[3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-3H-purin-6-one

Biological Activity

[Description]:

4’-Thioinosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
2.07g/cm3

[ Boiling Point ]:
708ºC at 760mmHg

[ Molecular Formula ]:
C10H12N4O4S

[ Molecular Weight ]:
284.29

[ Exact Mass ]:
284.05800

[ PSA ]:
149.56000

[ Index of Refraction ]:
1.935

Related Compounds