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Urea-13C,15N2

Names

[ CAS No. ]:
58069-83-3

[ Name ]:
Urea-13C,15N2

[Synonym ]:
urea<15N2-13C>
<13C,15N2>urea
MFCD00145506

Biological Activity

[Description]:

Urea-13C,15N2 is the 13C and 15N labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7.  

[3]. Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 1519(11):20392.Wang H, et al. Urea. Subcell Biochem. 201473:7-29.  

[4]. Wang H, et al. Urea. Subcell Biochem. 201473:7-29.  

Chemical & Physical Properties

[ Density]:
1.212g/cm3

[ Melting Point ]:
132-135ºC(lit.)

[ Molecular Formula ]:
CH4N2O

[ Molecular Weight ]:
63.03470

[ Exact Mass ]:
63.02980

[ PSA ]:
69.11000

[ LogP ]:
0.42440

[ Index of Refraction ]:
1.468

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
36/37/38-40

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Related Compounds