<Suppliers Price>

p38 MAP Kinase Inhibitor III

Names

[ CAS No. ]:
581098-48-8

[ Name ]:
p38 MAP Kinase Inhibitor III

[Synonym ]:
(S)-p38 MAPK Inhibitor III
2-Pyridinamine, 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-
4-[5-(4-Fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamine

Biological Activity

[Description]:

p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an 50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with 50 values of 0.37 μM and 0.044 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Research Areas >> Inflammation/Immunology

[Target]

p38 MAP kinase:0.9 μM (IC50)


[References]

[1]. Stefan A Laufer, et al. Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
589.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H21FN4S

[ Molecular Weight ]:
404.503

[ Flash Point ]:
310.2±32.9 °C

[ Exact Mass ]:
404.147095

[ LogP ]:
4.78

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.675

Related Compounds